Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values<0.05). Survival analyses revealed age, male gender, shortness of breath, cerebrovascular disease, and COPD as mortality-associated factors. Survival time from symptom onset was significantly shorter in elderly versus young patients (median: 29 versus 62 days), males versus females (median: 46 versus 59 days), and patients with versus without comorbidities (mean: 41 versus 61 days). Mortality risk was higher in elderly males with comorbidities than in young females without comorbidities (p-value<0.01). Elderly male survivors with comorbidities also had longer hospital stays than other survivors (25 versus 18.5 days, p-value<0.01). Overall, the high mortality risk in elderly males with COVID-19-associated comorbidities supports early prevention and critical care for elderly populations.

Original publication

DOI

10.18632/aging.202456

Type

Journal article

Journal

Aging (Albany NY)

Publication Date

31/12/2020

Volume

13

Pages

27 - 60

Keywords

COVID-19, SARS-CoV-2, comorbidities, mortality, risk factors, Adolescent, Adult, Aged, Aging, COVID-19, Cardiovascular Diseases, Cerebrovascular Disorders, Child, Child, Preschool, Cohort Studies, Comorbidity, Female, Global Health, Humans, Infant, Liver Diseases, Male, Middle Aged, Pulmonary Disease, Chronic Obstructive, Respiratory Tract Diseases, Risk Factors, SARS-CoV-2, Tuberculosis, Young Adult