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Neutrophil elastase and myeloperoxidase enzymes have been implicated in high-fat diet-induced obesity, insulin resistance (IR) and atherosclerosis in animal models. The aim of the present study was to explore neutrophil elastase and myeloperoxidase mRNA expressions in the peripheral blood leukocytes (PBL) in overweight and obese subjects, and to correlate those mRNA expressions with BMI, IR and cardiovascular biomarkers. In this cross-sectional study, 74 apparently healthy subjects including 22 lean, 27 overweight and 25 obese subjects were recruited. Cardiovascular and metabolic biomarkers were evaluated from fasting blood samples. The mRNA levels of neutrophil elastase and myeloperoxidase genes in the PBL were quantified by real-time PCR. Compared to lean group, the overweight and obese groups showed significant upregulation of both neutrophil elastase (p 

Original publication

DOI

10.1007/s11033-018-4279-4

Type

Journal article

Journal

Mol Biol Rep

Publication Date

10/2018

Volume

45

Pages

1245 - 1252

Keywords

Cardiovascular disease, Gene expression, Myeloperoxidase, Neutrophil elastase, Obesity, Adult, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Female, Genetic Predisposition to Disease, Humans, Insulin Resistance, Leukocyte Elastase, Male, Obesity, Overweight, Peroxidase, Triglycerides, Up-Regulation