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BACKGROUND: Dysregulated immune responses may contribute to the clinical complications that occur in some patients with dengue. FINDINGS: In Vietnamese pediatric dengue cases randomized to early prednisolone therapy, 81 gene-transcripts (0.2% of the 47,231 evaluated) were differentially abundant in whole-blood between high-dose (2 mg/kg) prednisolone and placebo-treated patients two days after commencing therapy. Prominent among the 81 transcripts were those associated with T and NK cell cytolytic functions. Additionally, prednisolone therapy was not associated with changes in plasma cytokine levels. CONCLUSION: The inability of prednisolone treatment to markedly attenuate the host immune response is instructive for planning future therapeutic strategies for dengue.

Original publication

DOI

10.1371/journal.pntd.0002592

Type

Journal article

Journal

PLoS Negl Trop Dis

Publication Date

2013

Volume

7

Keywords

Adolescent, Child, Child, Preschool, Cytokines, Dengue, Female, Gene Expression Profiling, Humans, Immunologic Factors, Immunomodulation, Killer Cells, Natural, Male, Placebos, Prednisolone, T-Lymphocytes, Cytotoxic, Treatment Failure, Vietnam, Young Adult