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The wMel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that wMel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The wMel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals. This is explained by an increased susceptibility of field-reared wild-type mosquitoes to infection than laboratory-reared counterparts. Collectively, these field- and clinically relevant findings support the continued careful field-testing of wMel introgression for the biocontrol of Ae. aegypti-born arboviruses.

Original publication

DOI

10.1073/pnas.1715788115

Type

Journal article

Journal

Proc Natl Acad Sci U S A

Publication Date

09/01/2018

Volume

115

Pages

361 - 366

Keywords

Aedes aegypti mosquito, dengue virus, extrinsic incubation period, virus transmission, wMel Wolbachia, Aedes, Animals, Dengue, Dengue Virus, Humans, Logistic Models, Mosquito Vectors, Pest Control, Biological, Time Factors, Viremia, Wolbachia