Short Communication: Lack of Effect of Maraviroc Intensification on Blood and Gut Reservoir.

Tiraboschi J., Ray S., Patel K., Pace M., Phalora P., Robinson N., Hopkins E., Meyerowitz J., Wang Y., Davies O., Mant C., Cason J., Kaye S., Sanderson J., Fidler S., Klenerman P., Frater J., Fox J.

We show that intensification of treatment with maraviroc in patients chronically infected with HIV-1 receiving successful long-term antiretroviral therapy was not associated with improvements in HIV-related morbidity, HIV reservoir, microbial translocation, immune activation, or immune exhaustion in either gut or peripheral blood. The measurement of reservoir in both gut and blood longitudinally contributes to a paucity of data in the area.

DOI

10.1089/AID.2016.0198

Type

Journal article

Publication Date

2017-02-01T00:00:00+00:00

Volume

33

Pages

143 - 146

Total pages

3

Keywords

HIV, antiretroviral therapy, immune activation, microbial translocation, viral reservoirs, Blood, CCR5 Receptor Antagonists, Cyclohexanes, Gastrointestinal Tract, HIV Infections, Humans, Male, Maraviroc, Middle Aged, Pilot Projects, Prospective Studies, Treatment Outcome, Triazoles

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