Wellcome Trust Sir Henry Dale Fellow
My main research focus is understanding host pathogen interactions using genetic data and developing statistical methods to integrate heterogeneous sources of data in infectious diseases. Traditionally, genetic studies of infectious diseases have sought to explain between-individual variation in disease phenotypes by assessing genetic factors separately in humans or pathogens, under the assumption that these factors are independent. Although reasonable for some variants, there is strong evidence that genetic interactions between host and viruses play a major role in viral disease aetiology. My aim is to integrate host and viral genomic data from the same patients to better understand viral pathogenesis and between-individual heterogeneity in disease outcomes. We are generating and analysing paired host-virus genomic data from large and well-characterised HBV, HCV and HIV infected cohorts and will investigate (a) host polymorphisms linked with viral sequence variation, (b) virus sites under strong host genetic selective pressures, (c) host and virus genetic factors independently contributing to disease phenotypes and (d) host-virus genetic interactions contributing to disease phenotypes.
My research is interdisciplinary, and I am interested in a wide range of subjects. Methodology and application areas include: Statistical Genetics, Bayesian Statistics, Machine Learning, Population Genetics, Bioinformatics, Immunology, Pathogen Evolution, Microbiology and Host-Pathogen Interaction.