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CXCR4-tropic (X4) HIV-1 variants are associated with faster disease progression compared with CCR5-tropic variants; however, the mechanism for this is unclear. We measured T-cell activation in 120 individuals with primary HIV-1 infection. X4-utilizing variants, determined genotypically, were present in 8.3% of the participants and were associated with higher levels of CD4 T-cell activation, even after adjusting for other prognostic factors. Increased CD4 T-cell activation may influence the more rapid immunological decline associated with X4 virus.

Original publication

DOI

10.1097/QAD.0b013e328351e721

Type

Journal article

Journal

AIDS

Publication Date

24/04/2012

Volume

26

Pages

887 - 890

Keywords

Adult, Biomarkers, CD4-Positive T-Lymphocytes, Disease Progression, Female, HIV Infections, HIV-1, Humans, Lymphocyte Activation, Male, Receptors, CCR5, Receptors, CXCR4