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Hepatitis E virus sequences were detected by RT-PCR in 14/15 (93%) of untreated sewage samples from Edinburgh, Scotland, UK. Phylogenetic analysis of amplicons at limiting dilution revealed the co-circulation of multiple variants of HEV-3, with a pattern of diversity matching that observed in a local cohort of HEV-infected hepatitis patients.

Original publication

DOI

10.1002/jmv.24403

Type

Journal article

Journal

J Med Virol

Publication Date

05/2016

Volume

88

Pages

915 - 918

Keywords

detection, epidemiology, variation, Epidemiological Monitoring, Genetic Variation, Genotype, Hepatitis E, Hepatitis E virus, Humans, Mass Screening, Phylogeny, Reverse Transcriptase Polymerase Chain Reaction, Scotland, Sewage