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In January to February 2014, 16 hand, foot and mouth disease (HFMD) cases were identified in Edinburgh, United Kingdom. All presented with atypical features, with most (n=13) resembling eczema herpeticum or chickenpox. Coxsackievirus A6 (CV-A6) was identified in all the typed cases (n=11). As atypical forms of HFMD associated with CV-A6 are likely to emerge throughout Europe, clinicians should be alert to unusual clinical presentations of HFMD and virologists aware of effective diagnostic testing and enterovirus typing methods.

Original publication




Journal article


Euro Surveill

Publication Date





Adult, Chickenpox, Child, Preschool, Coxsackievirus Infections, Diagnosis, Differential, Disease Outbreaks, Enterovirus A, Human, Female, Hand, Foot and Mouth Disease, Humans, Infant, Kaposi Varicelliform Eruption, Male, Middle Aged, RNA, Viral, Real-Time Polymerase Chain Reaction, Retrospective Studies, Sentinel Surveillance, Sequence Analysis, DNA, United Kingdom