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To investigate the frequency of oseltamivir resistance in circulating strains of the 2009 influenza A(H1N1) pandemic virus in Scotland, 1,802 samples from 1,608 infected hospitalised patients were screened by the H275Y discriminatory RT-PCR. Among these, we identified 10 patients who developed the H275Y mutation. All of them were immunocompromised and were under treatment or had been treated previously with oseltamivir.

Type

Journal article

Journal

Euro Surveill

Publication Date

08/04/2010

Volume

15

Keywords

Drug Resistance, Viral, Follow-Up Studies, Hospitalization, Humans, Immunocompromised Host, Influenza A Virus, H1N1 Subtype, Influenza, Human, Oseltamivir, Pandemics, Scotland