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A xenotropic murine leukemia virus-related virus (XMRV) has recently been reported in association with prostate cancer and chronic fatigue syndrome, with a prevalence of up to 3.7% in the healthy population. We looked for XMRV in 230 patients with human immunodeficiency virus type 1 or hepatitis C infection. XMRV was undetectable in plasma or peripheral blood mononuclear cells by polymerase chain reaction targeting XMRV gag or env. T cell responses to XMRV Gag were undetectable in peripheral blood mononuclear cells by ex vivo gamma interferon enzyme-linked immunospot assay. In our cohorts, XMRV was not enriched in patients with blood-borne or sexually transmitted infections from the United Kingdom and Western Europe.

Original publication

DOI

10.1086/657167

Type

Journal article

Journal

J Infect Dis

Publication Date

15/11/2010

Volume

202

Pages

1482 - 1485

Keywords

Adult, Aged, Cohort Studies, Enzyme-Linked Immunosorbent Assay, Europe, Female, Gene Products, gag, Genes, Viral, HIV Infections, HIV-1, Hepatitis C, Chronic, Humans, Interferon-gamma, Leukemia Virus, Murine, Leukocytes, Mononuclear, Male, Middle Aged, Polymerase Chain Reaction, Retroviridae Infections, Risk Factors, Tumor Virus Infections, United Kingdom, Viral Envelope Proteins, Young Adult