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The first proteomic characterization of the HepaRG cell line, the only cell line that is susceptible to hepatitis B virus (HBV) infection and supports a complete virus life cycle, is reported. Differential analysis of naive and HBV-infected HepaRG cells by two-dimensional gel electrophoresis revealed 19 differentially regulated features, 7 increasing and 12 decreasing with HBV infection. The proteins identified in these features were involved in various cellular pathways including apoptosis, DNA/RNA processing, and hepatocellular impairment. Similar expression changes in a number of the identified proteins have already been reported for other virus systems. Identification of these expression changes is a validation of the proteomics approach and contributes to an understanding of host cellular response to HBV infection.

Original publication




Journal article


J Proteome Res

Publication Date





118 - 122


Apoptosis, Cell Line, DNA, Electrophoresis, Gel, Two-Dimensional, Hepatitis B, Hepatitis B virus, Hepatocytes, Humans, Image Processing, Computer-Assisted, Mass Spectrometry, Phenotype, Proteome, Proteomics, RNA