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Many studies have been designed to address the role of CTL immune escape in HIV-1 infection, but have not given conclusive answers. Now, an elegant longitudinal analysis clearly demonstrates that progression to disease in SIV-infected macaques is associated with evasion of the CTL response (pages 1270-1276).

Original publication

DOI

10.1038/15184

Type

Journal article

Journal

Nat Med

Publication Date

11/1999

Volume

5

Pages

1233 - 1235

Keywords

Animals, Disease Progression, Epitopes, HIV Core Protein p24, HIV-1, Longitudinal Studies, Macaca, Simian Acquired Immunodeficiency Syndrome, T-Lymphocytes, Cytotoxic