Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

One of the important issues in dendritic cell (DC) biology today is how DC control the fate of T cells. Our data suggest that an important branch point in determining T cell fate is the decision between deletion and memory. We have previously hypothesized that this binary decision is determined by contact with DC derived from lymphoid- versus myeloid-restricted progenitors. However, the false attribution of CD8alpha expression as a reliable marker of lymphoid origin has underpinned a number of studies in which DC expressing CD8alpha did not induce deletion, thereby clouding the issue of whether deletion is indeed a function of lymphoid DC. By returning to basics, that is, functional testing of the progeny of lymphoid- and myeloid-restricted progenitors in vivo, we hope to provide clear evidence of the in vivo roles of lymphoid and myeloid DC subsets, independent of assumptions about the surface phenotypes they can assume.

Original publication

DOI

10.1046/j.1440-1711.2002.01117.x

Type

Journal article

Journal

Immunol Cell Biol

Publication Date

10/2002

Volume

80

Pages

469 - 476

Keywords

Animals, Antigen Presentation, Biological Evolution, CD8 Antigens, Cell Lineage, Clonal Deletion, Dendritic Cells, Histocompatibility Antigens Class II, Immune Tolerance, Immunologic Memory, Immunophenotyping, Lymphocytes, Mice, Mice, Transgenic, Myeloid Cells, Spleen, T-Lymphocyte Subsets, Vertebrates