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We conducted voluntary Covid-19 testing programmes for symptomatic and asymptomatic staff at a UK teaching hospital using naso-/oro-pharyngeal PCR testing and immunoassays for IgG antibodies. 1128/10,034 (11.2%) staff had evidence of Covid-19 at some time. Using questionnaire data provided on potential risk-factors, staff with a confirmed household contact were at greatest risk (adjusted odds ratio [aOR] 4.82 [95%CI 3.45-6.72]). Higher rates of Covid-19 were seen in staff working in Covid-19-facing areas (22.6% vs. 8.6% elsewhere) (aOR 2.47 [1.99-3.08]). Controlling for Covid-19-facing status, risks were heterogenous across the hospital, with higher rates in acute medicine (1.52 [1.07-2.16]) and sporadic outbreaks in areas with few or no Covid-19 patients. Covid-19 intensive care unit staff were relatively protected (0.44 [0.28-0.69]), likely by a bundle of PPE-related measures. Positive results were more likely in Black (1.66 [1.25-2.21]) and Asian (1.51 [1.28-1.77]) staff, independent of role or working location, and in porters and cleaners (2.06 [1.34-3.15]).

Original publication

DOI

10.7554/eLife.60675

Type

Journal article

Journal

Elife

Publication Date

21/08/2020

Volume

9

Keywords

Covid-19, SARS-CoV-2, epidemiology, global health, healthcare workers, risk factors, serology, symptoms, virus, Adolescent, Adult, Age Factors, Aged, Asymptomatic Infections, Betacoronavirus, Coronavirus Infections, Female, Health Personnel, Hospitals, Teaching, Humans, Incidence, Infectious Disease Transmission, Patient-to-Professional, Intensive Care Units, Male, Middle Aged, Pandemics, Pneumonia, Viral, Risk, Surveys and Questionnaires, United Kingdom, Young Adult