HIV-1 evades a gag mutation that abrogates KIR binding and disinhibits NK cells in infected individuals with KIR2DL2+/HLA-C*03: 04+ genotype.
Ziegler MC., Naidoo K., Chapel A., Nkotwana S., Mann J., Mncube Z., Ismael N., Goulder P., Ndung'u T., Altfeld M., Thobakgale CF.
: HIV-1 sequence variations impact binding of inhibitory killer cell immunoglobulin-like receptors (KIRs) to human leucocyte class I (HLA-I) molecules modulating NK cell function. HIV-1 strains encoding amino acids that mediate binding of inhibitory KIRs might therefore have a selective benefit in individuals expressing the respective KIR/HLA genotypes. Here we demonstrate that HIV-1 clade C avoids a p24 Gag mutation that abolishes binding of KIR2DL2 to HLA-C03:04 and disinhibits NK cells in individual encoding for this genotype.