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Guillain-Barré syndrome (GBS) and Miller-Fisher syndrome (MFS) are correlated with prior infection by Campylobacter jejuni in up to 40% of cases. Nucleotide sequence-based typing of 25 C. jejuni isolates associated with neuropathy permitted robust comparisons with equivalent data from approximately 800 C. jejuni isolates not associated with neuropathy. A total of 13 genetic lineages and 20 flaA short variable region nucleotide sequences were present among the 25 isolates. A minority of isolates (4 of 25) had the flaA short variable region nucleotide sequences that were previously proposed as a marker for GBS-associated isolates. These 4 isolates probably represented the Penner serotype 19 lineage, which has been proposed to have an association with GBS.

Original publication

DOI

10.1128/jcm.39.9.3346-3349.2001

Type

Journal article

Journal

J Clin Microbiol

Publication Date

09/2001

Volume

39

Pages

3346 - 3349

Keywords

Bacterial Typing Techniques, Base Sequence, Campylobacter Infections, Campylobacter jejuni, DNA, Bacterial, Flagella, Flagellin, Genetic Variation, Guillain-Barre Syndrome, Humans, Miller Fisher Syndrome, Molecular Sequence Data, Sequence Analysis, DNA, Serotyping