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There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the ultimate failure of the CTL response to control this virus infection.

Type

Conference paper

Publication Date

1995

Volume

22

Pages

51 - 62

Keywords

Acquired Immunodeficiency Syndrome, Antigens, Viral, Epitopes, Histocompatibility Antigens Class I, Humans, Peptides, T-Lymphocytes, Cytotoxic