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Blood donors are routinely screened for hepatitis C virus infection. Some individuals have weak or restricted virus-specific antibody responses, and are classed as indeterminate. Such donors are almost always negative for viral RNA in blood. We postulated that previous transient virus exposure might account for some of these cases. With sensitive ex-vivo analyses of T-cell responses, we identified virus-specific responses in 15 of 30 indeterminate blood donors tested, compared with none in controls (p=0.0013). Additionally, these responses were typically focused on core-derived peptides. These findings suggest previous exposure to the virus in many indeterminate blood donors.

Original publication

DOI

10.1016/S0140-6736(05)17787-3

Type

Journal article

Journal

Lancet

Publication Date

22/01/2005

Volume

365

Pages

327 - 329

Keywords

Adult, Aged, Antigen-Antibody Reactions, Blood Donors, Female, Hepacivirus, Hepatitis C, Hepatitis C Antibodies, Hepatitis C Antigens, Humans, Immunoblotting, Immunoenzyme Techniques, Male, Middle Aged, RNA, Viral, T-Lymphocytes, Viral Core Proteins