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Plasmodium falciparum, the most virulent species of human malaria parasite, causes 1-3 million deaths per year. Because this parasite is susceptible to naturally acquired host immunity the main burden of diseases falls on young children. The mechanism of this immunity is still unclear. However, the parasite makes a considerable investment in the insertion of highly polymorphic antigens (parasite-infected-erythrocyte surface antigens, PIESA) on the infected erythrocyte surface, and these antigens are potentially important immune targets.

Original publication

DOI

10.1016/s0966-842x(01)02278-8

Type

Journal article

Journal

Trends Microbiol

Publication Date

02/2002

Volume

10

Pages

55 - 58

Keywords

Animals, Antibodies, Protozoan, Antigens, Protozoan, Antigens, Surface, Erythrocytes, Humans, Immunity, Active, Malaria, Malaria, Falciparum, Plasmodium falciparum, Protozoan Proteins