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: The impact of antiretroviral therapy (ART) on the size of the HIV reservoir has implications for virological remission in adults, but is not well characterized in perinatally acquired infection. In a prospective observational study of 20 children with perinatally acquired infection and sustained viral suppression on ART for more than 5 years, proviral DNA was significantly higher in deferred (>4 years) versus early (first year of life) ART recipients (P = 0.0062), and correlated with age of initiation (P = 0.13; r = 0.57). No difference was seen in cell-associated viral RNA (P = 0.36). Identifying paediatric populations with smaller reservoirs may inform strategies with potential to induce ART-free remission.

Original publication

DOI

10.1097/QAD.0000000000001565

Type

Journal article

Journal

AIDS

Publication Date

24/08/2017

Volume

31

Pages

1847 - 1851

Keywords

Adolescent, Age Factors, Anti-Retroviral Agents, Antiretroviral Therapy, Highly Active, Child, DNA, Viral, Female, HIV Infections, Humans, Male, Perinatal Care, Prospective Studies, Secondary Prevention, Sustained Virologic Response, Treatment Outcome