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This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.

Original publication

DOI

10.1016/j.vaccine.2015.09.103

Type

Journal article

Journal

Vaccine

Publication Date

10/12/2015

Volume

33

Pages

7061 - 7068

Keywords

Clinical research, Dengue, Immunology, Pathogenesis, Vaccine, Virology, Adaptive Immunity, Dengue, Diagnostic Tests, Routine, Host-Pathogen Interactions, Humans, Immune Evasion, Immunity, Cellular, Immunity, Humoral, Immunity, Innate, Immunotherapy