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Recent anecdotal reports of HIV-infected children who received early antiretroviral therapy (ART) and showed sustained control of viral replication even after ART discontinuation have raised the question of whether there is greater intrinsic potential for HIV remission, or even eradication ('cure'), in paediatric infection than in adult infection. This Review describes the influence of early initiation of ART, of immune ontogeny and of maternal factors on the potential for HIV cure in children and discusses the unique immunotherapeutic opportunities and obstacles that paediatric infection may present.

Original publication




Journal article


Nat Rev Immunol

Publication Date





259 - 271


Antibodies, Neutralizing, Antiretroviral Therapy, Highly Active, Child, Child, Preschool, Early Medical Intervention, Female, HIV Infections, Humans, Infant, Infant, Newborn, Infectious Disease Transmission, Vertical, Lymphocyte Activation, Pregnancy, Pregnancy Complications, Infectious, Time Factors