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The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.

Original publication




Journal article


J Virol

Publication Date





7185 - 7190


Amino Acid Sequence, Animals, Base Sequence, Flaviviridae, Flaviviridae Infections, Horse Diseases, Horses, Molecular Sequence Data, Phylogeny, Prevalence, Sequence Analysis, DNA, Species Specificity, United States, Viremia