Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Markers of immune function present before infection may determine the subsequent course of disease in HIV-infected individuals. In 1983, we measured immune function in a group of haemophiliacs in Edinburgh. In 1984, 18 of these patients became infected with HIV-1 from contaminated factor VIII. We have followed-up these patients since their seroconversion. The rate of disease progression, as assessed by the appearance or not of AIDS symptoms or signs within five years of seroconversion, was related both to the concentration of total plasma IgM before exposure to infection and to the pattern of specific IgM and IgA anti-HIV response around the time of IgG seroconversion. Disease progression also correlated with concentrations of plasma interleukin-2 receptor (a marker of lymphocyte activation) and with the number and percentage of circulating DR + ve (activated) T cells. Our findings show that the extent of host immune reactivity, which may be genetically determined, is a powerful factor in the pathogenesis of HIV-associated disease.

Original publication

DOI

10.1016/0140-6736(91)92029-2

Type

Journal article

Journal

Lancet

Publication Date

09/11/1991

Volume

338

Pages

1159 - 1163

Keywords

Acquired Immunodeficiency Syndrome, Biomarkers, Drug Contamination, Factor VIII, Follow-Up Studies, HIV Seropositivity, HIV-1, Hemophilia A, Humans, Immunoglobulin A, Immunoglobulin M, Leukocyte Count, Longitudinal Studies, Lymphocyte Activation, Receptors, Interleukin-2, Scotland, T-Lymphocytes