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Of 32 patients exposed to a single batch of factor VIII contaminated with human immunodeficiency virus (HIV), 18 became antibody positive. Serial T cell subset analyses over the succeeding four years have shown a progressive decline in circulating T4 cells in those 18 but no change in the 14 who remain seronegative. 2 of the seroconverters have died and a further 7 have symptoms attributable to HIV infection. In the group as a whole, the HLA haplotype A1 B8 DR3 was weakly associated with an increased risk of seroconversion on exposure to the virus while, in those who seroconverted, it was strongly associated with a rapid decline in T4 cells and development of HIV-related symptoms within four years of infection.

Original publication

DOI

10.1016/s0140-6736(88)92009-0

Type

Journal article

Journal

Lancet

Publication Date

28/05/1988

Volume

1

Pages

1185 - 1188

Keywords

Adult, Antibodies, Viral, Drug Contamination, Factor VIII, Follow-Up Studies, HIV, HIV Antibodies, HIV Seropositivity, HLA Antigens, HLA-A1 Antigen, HLA-B8 Antigen, HLA-D Antigens, HLA-DR Antigens, HLA-DR3 Antigen, Haplotypes, Hemophilia A, Histocompatibility Testing, Humans, Male, Middle Aged, Risk Factors, T-Lymphocytes