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To investigate whether uncharacterized infectious agents were associated with neurologic disease, we analyzed cerebrospinal fluid specimens from 12 children with acute central nervous system infection. A high-throughput pyrosequencing screen detected human parvovirus 4 DNA in cerebrospinal fluid of 2 children with encephalitis of unknown etiology.

Original publication

DOI

10.3201/eid1708.110165

Type

Journal article

Journal

Emerg Infect Dis

Publication Date

08/2011

Volume

17

Pages

1484 - 1487

Keywords

Acute Disease, Adolescent, Antibodies, Viral, Child, Child, Preschool, DNA, Viral, Encephalitis, Viral, High-Throughput Nucleotide Sequencing, Humans, Immunoglobulin M, India, Molecular Sequence Data, Parvoviridae Infections, Parvovirus, Phylogeny, Polymerase Chain Reaction, Sequence Analysis, DNA