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Lectins and C-type lectins are a heterogeneous group of proteins with a diverse range of functions. Two C-type lectins, found in the Natural Killer gene Complex (NKC), Lectin-like transcript 1 (LLT1) and CD161, have recently gained interest from a broad range of immunological and non-immunological fields. LLT1 in particular has a diverse functional repertoire, from NK cell and B cell regulation to bone metabolism. This review seeks to bring together nearly two decades of research on these receptors and describe their importance in the immune system.

Original publication




Journal article


Immunol Lett

Publication Date





62 - 69


C-type lectin-like receptors, Carbohydrate recognition domain, Lectin-like transcript 1, Natural killer gene complex, Osteoclast inhibitory lectin, Animals, B-Lymphocytes, Bone and Bones, Humans, Immunity, Immunomodulation, Killer Cells, Natural, Lectins, C-Type, NK Cell Lectin-Like Receptor Subfamily B, Osteogenesis, Receptors, Cell Surface