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We report the near-full-length genome sequence of a hepatitis C virus (HCV) isolate from a man originating from Democratic Republic of Congo, the genotype of which could not be determined by the routinely used sequencing technique. The near-complete genome sequence of this variant BAK1 was obtained by the association of two next-generation sequencing technologies. Evolutionary analysis indicates that this isolate, BAK1, could be the first reported strain belonging to a new HCV-7b subtype. This new subtype has been incorrectly identified as genotype 2 by the Versant HCV Genotype 2.0 assay (LiPA). The requirement of three independent isolates has been filled, and a new subtype can be assigned. More examples of HCV-7 are required to better understand its origin, its pathogenicity and its relationship with genotype 2.

Original publication

DOI

10.1016/j.cmi.2016.07.032

Type

Journal article

Journal

Clin Microbiol Infect

Publication Date

11/2016

Volume

22

Pages

947.e1 - 947.e8

Keywords

Democratic Republic of Congo, Genotype 7b, Hepatitis C virus, Next-generation sequencing, Polymorphism, Evolution, Molecular, Genome, Viral, Genotype, Hepacivirus, High-Throughput Nucleotide Sequencing, Humans, Male, Middle Aged, Phylogeny, Sequence Analysis, DNA