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AIM: Even though systematic reviews have examined how aspects of propensity score methods are used, none has reviewed how the challenge of missing data is addressed with these methods. This review therefore describes how missing data are addressed with propensity score methods in observational comparative effectiveness studies. METHODS: Published articles on observational comparative effectiveness studies were extracted from MEDLINE and EMBASE databases. RESULTS: Our search yielded 167 eligible articles. Majority of these studies (114; 68%) conducted complete case analysis with only 53 of them stating this in the methods. Only 16 articles reported use of multiple imputation. CONCLUSION: Few researchers use correct methods for handling missing data or reported missing data methodology which may lead to reporting biased findings.

Original publication

DOI

10.2217/cer-2017-0071

Type

Journal article

Journal

J Comp Eff Res

Publication Date

03/2018

Volume

7

Pages

271 - 279

Keywords

comparative effectiveness, missing data, propensity score, Comparative Effectiveness Research, Data Collection, Humans, Observational Studies as Topic, Propensity Score